Chondroitin Sulfate Sodium 90%



Chondroitin Sulfate Sodium is a major component of human cartilage and is important in maintaining the structural integrity and proper functioning of joints. It is extracted from mammalian or avian cartilage and is available as a dietary supplement for patients suffering from joint pain due to cartilage degradation.

Chondroitin Sulfate Sodium, combined with Glucosamine, was part of an extensive five year study by the National Institute of Health evaluating joint pain relief. Chondroitin Sulfate Sodium, alone or in combination with Glucosamine, has been a dietary supplement taken to relieve joint pain for more than twenty years and continues to be a significant treatment for joint pain relief.


Pharmore Ingredients conducts ongoing robust auditing process to ensure that we are working with manufacturing plants that are committed to making a quality program and follow Good Manufacturing Practices (GMPs). We ensure that they implement a continuous improvement program with critical double checks throughout their process.  

Typical Process Flow:


Chondroitin Sulfate Sodium products supplied by Pharmore Ingredients are extracted from mammalian (bovine and/or porcine) or avian cartilage using a complex multistep extraction and precipitation process typically involving solvents like Ethanol.


Chondroitin Sulfate is a natural component of mammalian cartilage. The first step in extracting the Chondroitin from the cartilage is to liquify the cartilage using a high concentration of Sodium Hydroxide and water.


After the digestion step, the acid level is adjusted to neutral and enzymes are added to chemically separate the chondroitin from the liquified cartilage.


Chondroitin Sulfate is soluble in water, but not in alcohol. After cartilage digestion and enzyme treatment, alcohol is added to the solution that precipitates the Chondroitin out of the water.


To further remove water from the Chondroitin, the Chondroitin paste is placed in a high speed centrifuge to dry even further.


The semi-dry chondroitin is then placed in an oven and dried to a coarse powder.


Next, the dried chondroitin is milled to a fine powder, passed through a screen and magnet to remove any potential contaminants.


The Chondroitin is now a pure, free flowing powder that can be blended with other joint repair chemicals in a powder or capsule for use by the consumer.


Frequently Asked Questions:


1. Which cartilage source is best for me to use?

  • This really depends on your end use application. Costing varies due to availability of the cartilage source and the amount of CS that is able to be extracted from the cartilage source.

2. Is BSE a concern when using CS derived from bovine cartilage?

  • Pharmore certifies that the CS supplied is BSE Free. We are able to state this because the country of origin for the cartilage and the manufacturer is not listed on the published BSE Country in accordance with 9 CFA 94.18. We also get a Veterinary Health Certificate with the required information per Pharmore’s import permit for the bovine sourced product.

3. How do I calculate potency when formulating?

  • This was challenging for many of our customers years ago but thanks to our assistance this can be overcome.
    • First you need to decide on how you refer to the CS on the label and formulate for the complex that you are claiming. For Example: Chondroitin, Chondroitin Sulfate and Chondroitin Sulfate Sodium are all different. Pharmore can provide the content calculation sheet to assist you.
    • Secondly, CS has a very high content of moisture and you need to formulate based on As Is content not the typical Dry Basis content. This gets confusing when the ingredient potency discussed and being sold is on the Dry Basis content. Pharmore can provide an easy calculation conversion sheet to assist you that you can apply to any ingredient in your formulation.

4. What is the preferred testing method?

  • As many of you know, there has been much controversy over the years on how to test Chondroitin Sulfate Sodium. Pharmore Ingredients utilizes multiple test methods employed by USP to verify product conformance to specification requirements. The current USP monograph now includes the E-HPLC assay and an acceptable difference on assays derived by CPC and E-HPLC.
  • It is important to remember that assay is only one test and that is it critical to include FTIR for identity and even electrophoretic purity to ensure a quality product.

5. Does the source of the chondroitin(bovine, avian, porcine) have any affect on its effectiveness?

  • There have been no studies that indicate that one source of chondroitin is any more effective than other sources. It seems that once isolated, the chondroitin molecule is the same regardless of its starting material.(ie.,bovine, porcine, or avian)

6. Does the molecular weight of the chondroitin sulfate molecule affect how it works in the body?

  • There have been no reliable studies that have shown that one size of Chondroitin molecule is more or less effective than other sizes.



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